ORCID: 0000-0001-9885-3076

Resumen de investigación

Mi laboratorio está interesado en entender los mecanismos celulares y moleculares responsables del deterioro del sistema nervioso central, con especial énfasis en la interacción que existe entre el sistema inmune, microbiota y las células neuronales, y como esta interacción puede estar involucrada en la recuperación motora y/o neurológica en situaciones patológicas.

Productividad

Proyectos de Docencia y Vinculación con el Medio

Teaching and academic dissemination fund from Universidad Católica de la Santísima Concepción: “Difusión del Magister en Ciencias Biomédicas con foco en la comunidad científica nacional e internacional”. (Colaborator).

Proyectos de investigación

Equipment repair and maintenence fund from Universidad Católica de la Santísima Concepción 2023 (PI: Dr. Pia M. Vidal).

Applied research project (Proyecto interno de Investigación aplicada (DINNOVA)) from Universidad Católica de la Santísima Concepción 2023-2025 (PI: Dr. Pia M. Vidal).

Young IBRO (International Brain Research Organization) Grant 2022.

Equipment repair and maintenence fund from Universidad Católica de la Santísima Concepción 2021 (PI: Dr. Pia M. Vidal).

Scientific equipment acquisition fund from Universidad Católica de la Santísima Concepción 2021 (PI: Dr. Ariel Ávila; Co-investigator: Dr. Pia M. Vidal).

Fondecyt postdoctoral 3210384 (2021-2024) (Patrocinante: Dr. Pia M. Vidal).

FONDECYT Iniciación 11190421. 2019-2023 (PI: Dr. Pia M. Vidal).

Producción científica

Impaired communciation at the neuromotor axis during Degenerative Cervical Myelopathy. Ojeda J, Vergara M, Ávila A, Herniquez JP, Fehlings MG, Vidal PM. Front. Cell Neurosci 2024. Jan 10;17; doi: 10.3389/fncel.2023.1316432.

Farkas C, Retamal-Fredes E, Ávila A, Fehlings M, Vidal PM. Degenerative Cervical Myelopathy induces sex-specific dysbiosis in mice. Front. Microbiol. 2023. Oct 20;14:1229783. doi: 10.3389/fmicb.2023.1229783. eCollection).

Ulndreaj A, Ávila A, Hong J, Zhou C, Fehlings MG, Vidal PM. Acute Systemic White Blood Cell Changes following Degenerative Cervical Myelopathy (DCM) in a Mouse Model. Int J Mol Sci. 2022 Sep 29;23(19):11496. doi: 10.3390/ijms231911496.

Musleh-Vega S, Ojeda J, Vidal PM. Gut Microbiota-Brain Axis as a Potential Modulator of Psychological Stress after Spinal Cord Injury. Biomedicines. 2022 Apr 4;10(4):847. doi: 10.3390/biomedicines10040847.

Van Broeckhoven J, Erens C, Sommer D, Scheijen E, Sanchez S, Vidal PM, Dooley D, Van Breedam E, Quarta A, Ponsaerts P, Hendrix S, Lemmens S. Macrophage-based delivery of interleukin-13 improves functional and histopathological outcomes following spinal cord injury. J Neuroinflammation. 2022 Apr 29;19(1):102. doi: 10.1186/s12974-022-02458-2.

Ulndreaj A, Vidal PM, Forgione N, Hong J, Fehlings MG. IgM Immunoglobulin Influences Recovery after Cervical Spinal Cord Injury by Modulating the IgG Autoantibody Response. eNeuro. 2021 Sep 9;8(5):ENEURO.0491-19.2021. doi: 10.1523/ENEURO.0491-19.2021.

Ojeda J, Ávila A, Vidal PM. Gut Microbiota Interaction with the Central Nervous System throughout Life. J Clin Med. 2021 Mar 21;10(6):1299. doi: 10.3390/jcm10061299.

Laliberte AM, Karadimas SK, Vidal PM, Satkunendrarajah K, Fehlings MG. Mir21 modulates inflammation and sensorimotor deficits in cervical myelopathy: data from humans and animal models. Brain Commun. 2021 Jan 21;3(1):fcaa234. doi: 10.1093/braincomms/fcaa234. eCollection 2021.

Vidal PM, Pacheco R. The Cross-Talk Between the Dopaminergic and the Immune System Involved in Schizophrenia. 2020 Front Pharmacol. 11:394. doi: 10.3389/fphar.2020.00394. eCollection 2020.

Vidal PM, Ulndreaj A, Tetreault L, Hong J, Fehlings MG. The changes in systemic monocytes in humans undergoing surgical decompression for degenerative cervical myelopathy may influence clinical neurological recovery. 2019 J Neuroimmunol. Aug 16;336:577024. doi:10.1016/j.neuroim.2019.557024. [Epub ahead of print].

Productividad Científica anterior a la UCSC

Postdoctoral Research Fellow Award Competition Hinge, from Fundación Ciencia & Vida (2018-2020) (PI: Dr. Pia M. Vidal).

Postdoctoral & Clinical Research Fellow Award Competition from Kembil Research Institute (2016-2017) (PI: Dr. Pia M. Vidal).

2015 Cervical Spine Research Society (CSRS) 21^st Century Research and Education Grants (2015-2016) (PI: Dr. Michael Fehlings; Co-investigator: Dr. Pia M. Vidal).

2014 Cervical Spine Research Society (CSRS) 21^st Century Research and Education Grants (2015-2016) (PI: Dr. Michael Fehlings; Investigator: Dr. Pia M. Vidal).

Fonds Wetenschappelijk Onderzoek (FWO) Research project (2013-2016) (PI: Dr. Sven Hendrix; Investigator: Dr. Pia M. Vidal).

PhD scholarship from Transnational University Limburg, Belgium (2009-2013).

Sommer D, Corstjens I, Sanchez S, Dooley D, Lemmens S, Broeckhoven JV, Bogie J, Vanmierlo T, Vidal PM, Rose-John S, Gou-Fabregas M, Hendrix S. ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury. Brain Behav Immun. 2019 Mar 6. pii: S0889-1591(18)31201-7. doi: 10.1016/j.bbi.2019.02.032. [Epub ahead of print].

Badner A, Vidal PM, Hong J, Hacker J, Fehlings MG. Endogenous Interleukin-10 Deficiency Exacerbates Vascular Pathology in Traumatic Cervical Spinal Cord Injury. J Neurotrauma. 2019 Mar 7. doi: 10.1089/neu.2018.6081. [Epub ahead of print].

Vidal PM, Pacheco R. Targeting the dopaminergic system in autoimmunity. J Neuroimmune Pharmacol. 2019 Jan 19 doi: 10.1007/s11481-019-09834-5. [Epub ahead of print].

Vidal PM, Ulndreaj A, Badner A, Hong J, Fehlings MG. Methylprednisolone treatment enhances early recovery following surgical decompression for degenerative cervical myelopathy without compromise to the systemic immune system. J Neuroinflammation, 2018.

Vidal PM, Badner A, Maranon JA, Galan-Estella F, Caballero-Garrido E. The effect of animal weight on over ground locomotion in neurological diseases with a focus in CatWalk gait assessment. Cell Biology and Metabolism 2017 Dec.

Vidal PM, Karadimas SK, Ulndreaj A, Laliberte AM, Tetreault L, Forner S, Wang J, Foltz WD, Fehlings MGF. Delayed decompression exacerbates ischemia-reperfusion injury in cervical compressive myelopathy. JCI Insight 2017 Jun 2; 2(11).

Vangansewinkel T, Geurts N, Quanten K, Nelissen S, Lemmens S, Geboes L, Dooley D, Vidal PM, Pejler G, Hendrix S. Mast cells promote scar remodeling and functional recovery after spinal cord injury via mouse mast cell protease 6. FASEB J. 2016 May; 30(5):2040-57.

Ulndreaj A, Marbourg JM, Vidal PM. The complement receptor C5aR has a dual, time-dependent effect on the outcome of spinal cord injury. J Neurosci. 2015 Sep 9;35(36):12325-7.

Slaets H, Nelissen S, Janssens K, Vidal PM, Lemmens E, Stinissen P, Hendrix S, Hellings N. Oncostatin M Reduces Lesion Size and Promotes Functional Recovery and Neurite Outgrowth After Spinal Cord Injury. Mol Neurobiol. 2014 Dec; 50(3):1142-51.

Avila A, Vidal PM, Tielens S, Morelli G, Laguesse S, Harvey RJ, Rigo JM, Nguyen L. Glycine receptors control the generation of projection neurons in the developing cerebral cortex. Cell Death Differ. 2014 Nov; 21(11):1696-708.

Nelissen S, Vangansewinkel T, Geurts N, Geboes L, Lemmens E, Vidal PM, Lemmens S, Willems L, Boato F, Dooley D, Pehl D, Pejler G, Maurer M, Metz M, Hendrix S. Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4. Neurobiol Dis. 2014 Feb; 62:260-72.

1 Dooley D, Vidal PM, Hendrix S. Immunopharmacological intervention for successful neural stem cell therapy: new perspectives in CNS repair. Pharmacol Ther. 2014 Jan; 141 (1):21-3.1.

1 Vidal PM, Lemmens E, Avila A, Vangansewinkel T, Chalaris A, Rose-John S, Hendrix S. ADAM17 is a survival factor for microglial cells in vitro and in vivo after spinal cord injury in mice. Cell Death Dis. 2013 Dec 12; 4:e954. doi: 10.1038/cddis.2013.466.

Avila A, Vidal PM, Dear TN, Harvey RJ, Rigo JM, Nguyen L. Glycine receptor α2 subunit activation promotes cortical interneuron migration. Cell Rep. 2013 Aug 29;4(4):738-50.

1 Vidal PM, Lemmens E, Dooley D, Hendrix S. The role of “anti-inflammatory” cytokines in axon regeneration. Cytokines Growth Factor Rev, 2013 Feb;24(1):1-12.

1 Vidal PM, Lemmens E, Geboes L, Vangasewinkel T, Hendrix S. Late blocking of peripheral TNF-a is ineffective after spinal cord injury in mice. Immunobiology, 2013 Feb;218(2):281-4.